| Identified Thrust Areas | Sub-Areas |
| In-silico and rational drug design | Utilisation of artificial intelligence along with various computational tools for drug design for the following disorders:
|
| Synthesis of NCEs | Use of various synthetic approaches like:
|
| Lead identification and optimisation | Methodologies used for the development of potent NCEs include:
|
| Biological Evaluation of Potent NCEs | Biological evaluation of NCEs for the above-mentioned disorders by:
|
| Identified Thrust Areas | Sub-Areas |
| Phytopharmacological Evaluation of Herbal drugs and bioactives | Pharmacological evaluation of drugs of natural origin (plant, animals, marine & minerals) using various invitro/invivo/insilico techniques in the following areas:
Safety and toxicity studies for herbal drugs and natural bioactives |
| Nutraceuticals and Herbal Formulations | Formulation, Development, Evaluation and stability studies of
NDDS for targeted delivery of natural bioactives |
| Extraction, Isolation, separation of phytoconstituents and Analytical Method Development | Preparation of standardised herbal extracts and phytopharmaceuticals Isolation of various secondary metabolites from plants Separation and estimation of phytoconstituents Development of chromatographic fingerprinting for herbal extracts, herbal/Ayurvedic formulations Estimation of phytoconstituents by various spectroscopy and chromatography techniques |
| Quality control & standardisation | Development of plant monograph Standardisation of herbal drugs Standardisation of herbal and Ayurvedic formulations Value chain analysis of important medicinal plants |
| Identified Thrust Areas | Sub-Areas |
| Identification of novel therapeutic and molecular targets, pharmacological evaluation and development of novel experimental and surgical models | Neurological and cerebrovascular disorders Traumatic disorders Ageing and stress Cancer and cachexia Endocrine and metabolic disorders Cardiovascular diseases Gastrointestinal disorders Ophthalmic disorders Inflammation and immunological disorders Parasitic and infectious diseases Malnutrition and Blood disorders Environmental toxicity and Radiation injury |
| Bioinformatics, Safety Pharmacology, Pharmacokinetics, Toxicokinetics and Toxicity Studies and artificial intelligence using good laboratory practices (GLP) protocols | NCEs Peptide therapeutics Novel formulations Phytoconstituents Herbal/Ayurvedic extracts and formulations, functional foods Medical devices and diagnostics |
| Drug discovery and Formulation development and biological evaluation for various drug delivery systems | In-vitro studies Ex-vivo studies In-vivo studies PK-PD studies IVIVC PBPK |
| Clinical Research in compliance with Good Laboratory Practices (GLP) protocols and Good Clinical Practice (GCP) | Clinical trials Epidemiological studies Meta-analysis BA/BE studies Pharmacovigilance |
| Identified Thrust Areas | Sub-Areas |
| Dosage form development including nutraceuticals and cosmeceuticals | Study of process variables and formulation components for immediate and sustained/modified release dosage forms Novel dosage forms for oral cavity Nutraceuticals for malnourishment Cosmeceuticals for skin, hair etc. |
| Targeted Drug delivery systems for the treatment of various diseases like of cancer, diabetes, CVS diseases, CNS diseases, infectious diseases, wound healing etc. | Targeted drug delivery systems by various routes Applications for diagnosis and treatment |
| Micro/nano-based and vesicular drug delivery systems using QbD-DoE Approach | Development of industrially feasible cost effective formulation of various novel drug delivery systems like micro / nanoparticles, liposomes, niosomes, Complex injectables, etc. Development of Drug delivery systems for various routes like Oral, Parenteral, Topical, Transdermal, Ocular, Vaginal, Nasal, Pulmonary, etc. Polymer modification and Applications of 3D printing |
| Dissolution/Bioavailability Enhancement for poorly soluble drugs | Exploring commercial viable techniques like complexation, solid dispersion using melt extrusion etc Colloidal and nano-based based systems (Nanogel nanosuspension, micelles, Microemulsion, etc.) PK-PD studies of Pharmaceutical formulations |
| Identified Thrust Areas | Sub-Areas |
| Analytical Method Development and drug stability evaluation | QbD and AI-based stability indicating analytical and bioanalytical method development Methods for biosimilarity evaluation of biotherapeutics Pharmacokinetic studies of drugs and metabolites Degradation profiling of drug substance and drug products Pre-formulation assessment of drugs and drug-excipient compatibility studies |
| Herbal and Food Analysis | Standardisation of Indian traditional medicines and polyherbal formulations Determination and quantification of pesticide residues from food articles by various analytical techniques |
| Space Medicine | To find solutions for the challenges of providing healthcare in space and on physiological adaptations of humans to hostile environments To develop space hardy formulations to use in space To use Indian traditional medicine knowledge to maintain health during space travel To develop a microgravity and radiation experiment platform to perform experiments in zero-g flights atmosphere |
| Pharmaceutical Regulatory Affairs | Pharmacovigilance with respect to signal detection for ADR monitoring Study, review and compare various regulatory guideline on drug substance, drug product, biologics, nutraceuticals, medical device with a view to develop various regulatory documents for submission and registration of product |
