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Institute of Pharmacy

I. Department of Pharmaceutical Chemistry
Identified Thrust Areas Sub-Areas
In-silico and rational drug design Utilisation of artificial intelligence along with various computational tools for drug design for the following disorders:

  1. Cancer
  2. Diabetes and Obesity
  3. Cardiovascular diseases
  4. Diseases of International priority like HIV, Covid-19, etc.
  5. Diseases of National priority like Tuberculosis, Malaria, Dengue, Chikungunya, etc.
Synthesis of NCEs Use of various synthetic approaches like:

  1. Conventional and combinatorial synthesis
  2. Green chemistry
Lead identification and optimisation Methodologies used for the development of potent NCEs include:

  1. Hit to lead identification
  2. PK/PD profiling of potent NCEs
  3. Solubility enhancement by co-crystallisation, etc.
Biological Evaluation of Potent NCEs Biological evaluation of NCEs for the above-mentioned disorders by:

  1. In-vitro assays including, but not limited to, cytotoxicity studies, enzyme assays, apoptosis study, gene expression studies, western blot analysis, etc.
  2. In-vivo animal models for the above-mentioned disorders

 

II. Department of Pharmacognosy
Identified Thrust Areas Sub-Areas
Phytopharmacological Evaluation of Herbal drugs and bioactives Pharmacological evaluation of drugs of natural origin (plant, animals, marine & minerals) using various invitro/invivo/insilico techniques in the following areas:

  1. Neurodegenerative disorders
  2. Cancer
  3. Wound healing
  4. Diabetes
  5. Obesity
  6. Urolithiasis
  7. Antiinflammatory & Antioxidant

Safety and toxicity studies for herbal drugs and natural bioactives

Nutraceuticals and Herbal Formulations Formulation, Development, Evaluation and stability studies of

  1. Herbal formulations
  2. Herbal Cosmetics
  3. Nutraceuticals and dietary supplements
  4. Phytopharmaceuticals

NDDS for targeted delivery of natural bioactives
Novel approaches like surface conjugation, Polymeric nanoparticles for targeted brain delivery for management of neurodegenerative diseases like Alzheimer’s, Parkinson’s disease, Cancer and wound healing

Extraction, Isolation, separation of phytoconstituents and  Analytical Method Development Preparation of standardised herbal extracts and phytopharmaceuticals
Isolation of various secondary metabolites from plants
Separation and estimation of phytoconstituents
Development of chromatographic fingerprinting for herbal extracts, herbal/Ayurvedic formulations
Estimation of phytoconstituents by various spectroscopy and chromatography techniques
Quality control & standardisation Development of plant monograph
Standardisation of herbal drugs
Standardisation of herbal and Ayurvedic formulations
Value chain analysis of important medicinal plants

 

III. Department of Pharmacology
Identified Thrust Areas Sub-Areas
Identification of novel therapeutic and molecular targets, pharmacological evaluation and development of novel experimental and surgical models Neurological and
cerebrovascular disorders
Traumatic disorders
Ageing and stress
Cancer and cachexia
Endocrine and metabolic
disorders
Cardiovascular diseases
Gastrointestinal disorders
Ophthalmic disorders
Inflammation and immunological disorders
Parasitic and infectious diseases
Malnutrition and Blood disorders
Environmental toxicity and Radiation injury
Bioinformatics, Safety Pharmacology, Pharmacokinetics, Toxicokinetics and Toxicity Studies and artificial intelligence using good laboratory practices (GLP) protocols NCEs
Peptide therapeutics
Novel formulations
Phytoconstituents
Herbal/Ayurvedic extracts and formulations, functional foods
Medical devices and diagnostics
Drug discovery and Formulation development and biological evaluation for various drug delivery systems In-vitro studies
Ex-vivo studies
In-vivo studies
PK-PD studies
IVIVC
PBPK
Clinical Research in compliance with Good Laboratory Practices (GLP) protocols and Good Clinical Practice (GCP) Clinical trials
Epidemiological studies
Meta-analysis
BA/BE studies
Pharmacovigilance

 

IV: Department of Pharmaceutics
Identified Thrust Areas Sub-Areas
Dosage form development including nutraceuticals and cosmeceuticals Study of process variables and formulation components for immediate and sustained/modified release dosage forms
Novel dosage forms for oral cavity
Nutraceuticals for malnourishment
Cosmeceuticals for skin, hair etc.
Targeted Drug delivery systems for the treatment of various diseases like of cancer, diabetes, CVS diseases, CNS diseases, infectious diseases, wound healing etc. Targeted drug delivery systems by various routes
Applications for diagnosis and treatment
Micro/nano-based and vesicular drug delivery systems using QbD-DoE Approach Development of industrially feasible cost effective formulation of various novel drug delivery systems like micro / nanoparticles, liposomes, niosomes, Complex injectables, etc.
Development of Drug delivery systems for various routes like Oral, Parenteral, Topical, Transdermal, Ocular, Vaginal, Nasal, Pulmonary, etc.
Polymer modification and Applications of 3D printing
Dissolution/Bioavailability Enhancement for poorly soluble drugs Exploring commercial viable techniques like complexation, solid dispersion using melt extrusion etc
Colloidal and nano-based based systems (Nanogel nanosuspension, micelles, Microemulsion, etc.)
PK-PD studies of Pharmaceutical formulations

 

V. Department of Pharmaceutical Analysis
Identified Thrust Areas Sub-Areas
Analytical Method Development and drug stability evaluation QbD and AI-based stability indicating analytical and bioanalytical method development
Methods for biosimilarity evaluation of biotherapeutics
Pharmacokinetic studies of drugs and metabolites
Degradation profiling of drug substance and drug products
Pre-formulation assessment of drugs and drug-excipient compatibility studies
Herbal and Food Analysis Standardisation of Indian traditional medicines and polyherbal formulations
Determination and quantification of pesticide residues from food articles by various analytical techniques
Space Medicine To find solutions for the challenges of providing healthcare in space and on physiological adaptations of humans to hostile environments
To develop space hardy formulations to use in space
To use Indian traditional medicine knowledge to maintain health during space travel
To develop a microgravity and radiation experiment platform to perform experiments in zero-g flights atmosphere
Pharmaceutical Regulatory Affairs Pharmacovigilance with respect to signal detection for ADR monitoring
Study, review and compare various regulatory guideline on drug substance, drug product, biologics, nutraceuticals, medical device with a view to develop various regulatory documents for submission and registration of product

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